Shopping for a new mini split HVAC used to be about price and cooling power. The type of refrigerant, though, tends to be overlooked. There are a lot of refrigerants on the market. Among them, R-454B and R-410A are commonly used in modern air conditioner units. What does this all mean for you? This article will walk you through a comprehensive comparison of R-454B and R-410A. Once you learn their features, picking the right product gets a lot easier. Let’s have a close look!

What Are R-454B & R-410A Air Conditioner Refrigerants?

Refrigerant is the working as a medium in air conditioner systems to transfer heat and achieve the refrigeration or heating cycle. R-454B and R-410A are two types of refrigerants widely used. Although both refrigerants work the same way, they differ in terms of energy efficiency, environmental impact, and long-term suitability. 

What Is R-410A Refrigerant

R-410A is a kind of refrigerant that consists of a blend of HFCs. It is designed for efficient cooling. This refrigerant delivers fast temperature reduction and reliable performance. Nowadays, it works well in both residential and commercial cooling systems. 

Newer refrigerants with lower environmental impact are being developed. However, R-410A remains a practical choice for its proven effectiveness. Many high-quality air conditioners still rely on this refrigerant for optimal performance.

What Is R-454B Refrigerant

R-454B is a next-generation refrigerant developed as a more environmentally friendly alternative. It has a lower Global Warming Potential (GWP) compared to older refrigerants, which means it does less harm to the environment.

This refrigerant maintains strong cooling performance. At the same time, it improves energy efficiency, designed to meet stricter environmental regulations. Though newer, it offers compatibility with existing equipment so that it is a forward-looking choice for eco-conscious consumers.

If you’re buying a new air conditioner, the choice of refrigerant will likely depend on the system’s design and current regulations in your region. R-410A systems are still widely available and offer reliable performance. However, if long-term sustainability is important to you, R-454B may be the better option.

R-454B vs R-410A: Key Differences

Here is a quick comparison of the two refrigerants:

Best R-454B and R-410A Mini Split AC in 2025

These two refrigerants each have their pros and cons. Select one air conditioner unit that best suits your needs rather than focusing on only its features. We consider different aspects of the AC unit, and here are our highly recommended models you can choose from.

1. DELLA Econo Series Mini Split AC R-410A Refrigerant

The DELLA Mini Split Air Conditioner with 17 SEER2 is the most affordable choice for cooling various spaces ranging from a small bedroom to a medium-sized office. With a powerful cooling effect, this model can also heat your room efficiently due to its heat pump.

Key Features:

• Cooling Capacity: Perfectly suited for spaces of 550/1,000/1,500 sq. ft.. It brings ultimate comfort in different spaces.
• Energy Efficiency: With a 17 SEER2 rating, it ensures efficient performance and saves your energy costs by 22%.
• Quiet Operation: Running at just 30dB. It helps you experience peace and comfort with the unit's quiet operation. 
• All-Season Functionality: Equipped for both cooling and heating, this model ensures consistent and year-round comfort.

2. DELLA Vario Series Mini Split AC R-410A Refrigerant

If you’re looking for a powerful air conditioning solution for all spaces, the DELLA Vario Series Mini Split AC is an excellent choice. It is designed to cool areas from 400 to 1,500 sq. ft.. This energy-efficient system combines advanced features with easy installation, and it is the ideal solution for apartments, bedrooms, and offices. 

Key Features:

• All Range of Rooms: You can choose spaces of 400/550/1,000/1,500 sq. ft.. Wide range of cooling capacity of 9,000/12,000/18,000/24,000 Btu.
• Energy-Efficient: With a rate of 19 SEER2, this model ensures low energy consumption while maintaining powerful cooling efficiency.
• WiFi/APP Control: You can set your mini split unit remotely using the DELLA App.
• All-in-One Heating & Cooling: It is equipped with a built-in heat pump. Enjoy both cooling in the summer and heating in the winter.

3. DELLA Optima Series Mini-Split AC R-454B Refrigerant

The DELLA Optima Series 24 SEER2 Mini Split AC offers impressive features of both energy efficiency and powerful performance. It is one of the most energy-saving units. This mini split unit can provide optimal comfort for spaces up to 550 sq. ft. With its advanced inverter technology, it ensures a steady temperature without overworking.

Key Features:

• 24 SEER2 Efficiency: With a 24 SEER2 rating, it consumes significantly less energy than most traditional AC units. Save energy up to 72%.
• Eco-Friendly: Charged with R-454B refrigerant with only 466 GWP. It aligns with the future environmental rules.
• Cooling & Heating: This unit provides powerful cooling and heating capacity to maintain comfort year-round.
• Quiet Operation: The unit runs quietly at only 30dB. Maintain a peaceful environment while it cools or heats your space.
• Pre-Charged & Easy Installation: Comes pre-charged with refrigerant. It runs smoothly after easy installation steps.

4. DELLA Vario Series Mini Split AC R-454B Refrigerant

This DELLA Vario Series model is a high-efficiency HVAC solution. It is designed for spaces up to 550 sq. ft., a solid choice for standard living rooms and individual offices. With a SEER2 rating of 23, it offers outstanding energy savings and also reliable cooling effect. R-454B refrigerant is both efficient and environmentally responsible.

Key Features:

• Eco-Friendly Refrigerant: Uses R-454B refrigerant with a low GWP of 466. It is more sustainable and also aligned with future environmental regulations.
• High Energy Efficiency: SEER2 rating of 23 ensures excellent seasonal performance. Get lower electric bills at the same time.
• Cooling & Heating: 12,000 BTU provides strong cooling in summer. Similarly, it offers dependable heating even in low temperatures.
• Quiet Operation: Indoor unit operates at just 28 dB. It brings you a peaceful and comfortable environment.

Why Choose a Mini Split System?

Mini-split systems are known for their efficient cooling and energy savings. Generally, the systems feature a ductless design. There are also multi-zone mini splits, so that it’s convenient for you to install in every corner of your house, depending on your actual needs. Their flexibility, ease of installation, and individual zone control make them a great choice for homeowners seeking to enhance both comfort and efficiency.

Conclusion

Choosing the right refrigerant is crucial when purchasing a new air conditioning system. Both R-454B and R-410A offer excellent cooling performance. R-454B is the superior choice for those who want to minimize their environmental impact. While R-410A still offers great energy efficiency in a more mature market and technology. 

When you plan to upgrade your AC, a trustworthy brand like DELLA offers you high-performance and cost-effective mini splits. 

FAQ

Is R-454B more energy-efficient than R-410A?

Both refrigerants offer high efficiency. However, R-454B is becoming more common in new systems.

Is R-454B a better option for the environment?

Yes, R-454B has a significantly lower Global Warming Potential (GWP), which is a more eco-friendly choice.

Can I replace R-410A with R-454B in my existing AC?

No. R-454B is designed for use in newer systems. If your current system uses R-410A, replacing the refrigerant is not recommended due to safety concerns.

Related reading:

Can You Use a Mini Split As A Heater

Cooling Your Study Space: A 2025 Air Conditioner Buying Guide